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Differin Cream (Adapalene)

Adapalene, the active ingredient in Differin Cream, is a proven spot and inflammation reducing medication for acne. Adapalene belongs to a group of drugs called the retinoids – vitamin A derivatives and limits the growth of acne-causing cells. It is applied once a day on dry skin.
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Differin Cream (Adapalene)

Adapalene, the active ingredient in Differin Cream, is a proven spot and inflammation reducing medication for acne. Adapalene belongs to a group of drugs called the retinoids – vitamin A derivatives and limits the growth of acne-causing cells. It is applied once a day on dry skin.


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Differin Cream is a topical medication used for the treatment of mild to moderate acne. This includes acne vulgaris, comedones, papules, and pustules. The active ingredient in Differin Cream is Adapalene. This is a vitamin A derivative retinoid that reduces the growth of keratin cells on the surface of the skin to reduce the severity of acne pimples. Differin Cream is appropriate for treating acne on the face, chest, and back. 

Differin Cream is a retinoid medication recommended for the treatment of acne. This medication effectively reduces inflammation, swelling, blackheads, whiteheads, and pustules on the skin. Differin is a topical medicine applied over the affected area of the skin and is suitable for those who don’t prefer oral medication for acne.

Differin Cream works by reducing the growth of acne-causing cells, reducing swelling and inflammation. Acne is caused due to the blockage of skin pores. When the sebaceous gland produces excess sebum, it tends to mix with dead keratin skin cells to block the pores of your skin. The blocked pores then result in acne, in the form of blackheads, whiteheads, and spots. 

Applying Differin Cream to the affected area of the skin can clear the blocked pores to allow the sebum to escape. It promotes the natural exfoliation of the skin. The medication also reduces the occurrence of dead keratin skin cells thus reducing acne. 

Differin Cream is an effective topical remedy against acne. There are various benefits of using Differin –  

  • Differin heals acne by promoting the natural exfoliation of the skin that is effective in reducing acne

  • Differin Cream helps in reducing swelling and inflammation in the skin

  • Differin unblocks pores that are causing acne to treat the condition at the source

  • Differin Cream restores the natural smoothness and health of the skin

  • A reduction in acne helps you feel more confident about your skin

It is advisable to use Differin Cream as recommended by your prescription. For acne, usually, the recommended usage is once a day. It is important to use the medicine regularly to effectively treat acne. 

Use Differin Cream as advised by your prescription. Read the information leaflet provided inside the product packaging and follow the directions as given in the leaflet. Ask our pharmacist if you have any doubts about the usage of Differin Cream. Here is the usual method for using this medication –

  • Wash your hands with soap and dry them completely before application

  • Clean the affected area of your skin with water and soap, then gently pat the skin dry

  • Take a small amount (about the size of a pea) of Differin Acne Cream on your finger and gently spread it around the affected area of the skin

  • Apply the medication once a day (preferably before bedtime) or as directed by your doctor

  • This is a topical medication meant for external use only. Do not ingest

  • Do not use Differin Cream on broken, damaged, burnt, or eczema-affected skin

  • If you happen to get Differin Cream in your nose, mouth or eyes seek medical attention immediately

  • If you develop eye irritation when using Differin Cream, consult your doctor immediately

  • Use the medication regularly for the best results

There are some key facts to remember about Differin Cream. Please keep them in mind when using the medication.

  1. The key ingredient in Differin Cream is Adapalene. 

  1. Differin Cream is suitable for people of all ages but it should not be used by children below the age of 12 years. 

  1. Differin Cream is suitable for use on your face, chest, and back. It is not advisable to use Differin Acne Cream if you have large areas of skin affected by acne. 

  1. Using Differin Cream makes you susceptible to sunburn. Do not expose affected areas of the skin to direct sunlight, if you need to go outdoors, use a sunscreen of at least 30 SPF. 

  1. This is a topical medication meant for external use only. Do not ingest. 

  1. If you develop eye-irritation when using Differin Cream, consult your doctor immediately. 

Differin Cream is not suitable for everyone. You should not use this medication to treat your acne if you -

  • Have an allergy to Adapalene or any other ingredients of Differin Cream

  • Are already using some other kind of retinoid medication or any other medication for your acne 

  • This medication is not suitable for pregnant women

  • The medication is not suitable for breastfeeding women 

  • Have severe eczema or other skin conditions

  • Have acne affecting a large area of your skin

Like all medications, Differin too has the potential to sometimes cause side effects. Although most people who use this medicine don’t experience any problems or side effects some of the possible side effects of Differin Cream are –

  1. Skin discomforts such as dryness, redness, or itching

  1. Peeling of skin

  1. Sensitivity to sunlight. Increased susceptibility to sunburn

  1. Swelling of eyelids

It is not advisable to use Differin Cream with certain other medicines as it may reduce the effectiveness of Differin or cause other skin problems. When using Differin Cream avoid using skin products containing salicylic acid or glycolic such as facewashes and day creams. Do not use abrasive cleansers, strong drying products, or acne products with alcohol or astringent when using Differin Cream.

If you need to use additional acne treatments alongside Differin Cream, only use medications containing benzoyl peroxide, clindamycin, or erythromycin. Make sure to use these at different times of the day. For example, use Differin at night before going to bed and use the other medication in the morning.

You can buy Differin Cream online from MedsNow, a registered pharmacy in the UK. Please complete a consultation online with one of our clinicians who will issue you a prescription for you if clinically appropriate. The medication will bdelivered to your doorstep.

Store Differin Cream in a cool dry place. Always check the expiration date on the pack before using and dispose of any medication that has passed the expiration date. Keep away from the sight and reach of children at all times. 

How Long Does Differin Acne Cream Take To Work?

Usually, you may not notice any difference in your acne outbreak as soon as you begin using Differin Cream. It could take up to two weeks for positive results to be visible and it may be around 8-12 weeks before your acne completely clears up.

What if I Forget to Use Differin Cream?

If you forget to use Differin on a particular day, apply it as soon as you remember or at your regular time the next day. Then continue to use the medication as usual. For best results apply Differin regularly as prescribed.

When Should I Use Differin Acne Cream?

It is advisable to use Differin once a day before you go to bed.

Where Can I Use Differin Cream?

Differin is mostly recommended for treating an acne outbreak on your face, neck, chest, or back. If a large area of your skin is affected by acne, it is not advisable to use Differin. Consult your doctor for the right medication in such a case.

How Long Should I Use Differin Acne Cream For?

Use Differin Cream for as long as your doctor has prescribed. However, the usual length of treatment is two months before the treatment is reviewed. If Differin Cream usage is showing positive results for your skin, your doctor may ask you to use it for a few more weeks. In some cases, long-term use of Differin Cream may also be prescribed.

Is Differin Effective?

For the past many years, Differin Cream has proven to be an effective remedy against acne on various skin types. It helps to treat and prevent acne effectively.

Is Differin Creme Safe To Use Whilst Pregnant Or Breastfeeding?

Do not use Differin Cream if you are pregnant or breastfeeding.

Can I Use Differin With Other Products For Acne?

Avoid using Differin Cream if you are using other Retinoid medications for acne. If you need to use some other medication for acne alongside Differin, only use medications containing benzoyl peroxide, clindamycin, or erythromycin. Make sure to use these at different times of the day. For example, use Differin at night before going to bed and use the other medication in the morning.

What Is The Difference Between Differin Cream And Gel?

The Differin Cream is recommended for people with dry skin, while the Differin Gel is more suitable for people with oily skin. Differin Gel dries up easily and may irritate dry skin. For skin that is prone to dryness and irritation, use Differin Cream.

Can You Buy Differin Cream Over The Counter Without A Prescription?

In the UK, Differin is only available through prescription.

How to Buy Differin Cream Online?

You can buy Differin Cream online from MedsNow. Please complete a consultation online with one of our clinicians who will issue you a prescription if clinically appropriate. The medication will be delivered to your doorstep.

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