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Epiduo Gel (Adapalene)

Epiduo Gel is a combination medication containing Adapalene (a retinoid) and Benzoyl Peroxide (a skin-peeling treatment). It is a popular treatment for moderate to severe acne. Epiduo Gel inhibits the formation of blackheads and whiteheads by eradicating dead skin cells.
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Epiduo Gel (Adapalene)

Epiduo Gel is a combination medication containing Adapalene (a retinoid) and Benzoyl Peroxide (a skin-peeling treatment). It is a popular treatment for moderate to severe acne. Epiduo Gel inhibits the formation of blackheads and whiteheads by eradicating dead skin cells.


Epiduo Gel is a topical ointment recommended for the treatment of moderate to severe acne in adults. If you are suffering from acne vulgaris which includes the presence of comedones, blackheads, whiteheads, papules, and pustules – then we may prescribe Epiduo Gel for your treatment. This medication contains two active ingredients – 

  • Adapalene – This is a retinoid that helps unblock pores and sebaceous glands. This helps reduce inflammation and redness of the skin.

  • Benzoyl Peroxide – This is an anti-microbial ingredient that softens and peels the outer layer of the affected skin. This helps in clearing out the acne-causing bacteria from your skin.

Epiduo Gel is a prescription medication used for the treatment of a skin condition known as acne vulgaris. This includes pimples, blackheads, whiteheads, papules, and pustules. This medication is suitable only for people above the age of 12 years. Epiduo Gel unblocks the sebaceous glands and pores of the skin by improving the natural exfoliation of the skin. Thus clearing out the bacterial infection causing acne on your skin.

Acne is caused when the sebaceous glands in your skin produce excess sebum. Acne-causing bacteria known as Propionibacterium Acnes feed on the excess sebum causing irritation and inflammation in the sebaceous glands – which in turn, triggers acne.  

Epiduo Gel contains two active ingredients Adapalene and Benzoyl PeroxideAdapalene is a retinoid medicine that reduces inflammation, redness, and swelling in the skin. Benzoyl Peroxide eliminates acne-causing bacteria. It also peels off the outer layer of the affected skin through natural exfoliation.

Epiduo Gel is an effective treatment for acne on the face, chest, and back areas of the skin. There are various benefits of using Epiduo Gel. Some of them are listed below:

  1. Epiduo Gel is a topical treatment that is easy to use and suitable for everyone above the age of 12 years.

  1. Epiduo Gel dries out the greasiness of the skin to prevent future breakouts of acne.

  1. Epiduo Gel clears your skin of acne and restores the natural smoothness of your skin. This helps in making you feel confident and happy about your appearance.

  1. Epiduo Gel contains Benzoyl Peroxide which breaks down the keratin in the skin to effectively reduce the appearance of acne. It also has anti-bacterial properties that kill the acne-causing bacteria to remove the root cause of acne on your skin.

Epiduo Gel should be used as directed by your prescription. We will recommend the use of Epiduo depending upon the severity of your condition. Here is the usual recommended method for using Epidu:

  1. Wash the affected area of the skin thoroughly, using a gentle soap, and pat dry.

  1. Apply the recommended dosage of Epiduo Gel to the affected area of the skin.

  1. Do not apply Epiduo to broken or damaged areas of the skin.

  1. Avoid getting the gel into your eyes, nose, or mouth. If you do, rinse thoroughly with clean water.

  1. Wash your hands after applying Epiduo Gel.

  1. It is natural to experience a small amount of irritation on your skin due to the Benzoyl Peroxide in Epiduo Gel. If the skin irritation persists after a few weeks reduce the amount and/or frequency of application of the gel.

  1. If the skin irritation or soreness of the skin is too much, please arrange a review with us.

  1. Do not use more than the recommended amount of Epiduo as this increases the chance of skin irritation.

Epiduo Gel is a prescription medication and your doctor will tell you the right dose according to the severity of your acne. Usually, the recommended dosage is a pea-sized amount of Epiduo Gel to be applied to the affected area of your skin once a day.

Here is some important information about Epiduo Gel that you should know before using the medicine:

  1. Epiduo Gel is a suitable medication for the treatment of acne on your face, back, or chest.

  1. Epiduo Gel is to be applied thinly to the affected area of the skin once every day, preferably at bedtime.

  1. When using Epiduo Gel, protect all exposed areas of your skin with a good sunscreen lotion (with SPF 30 and above) when going outdoors in direct sunlight.

  1. When using Epiduo Gel, do not use sunbeds, or sunlamps.

  1. Epiduo Gel is not suitable for use by children below the age of 12 years.

  1. Epiduo Gel may bleach hair or coloured fabrics such as clothes, towels, or bed sheets. Be careful not to get the gel on these materials.

  1. Even though Epiduo Gel can start working immediately, some people may need to use this medication for almost two months before they begin to see an improvement in their acne.

Even though there are various benefits of using Epiduo Gel, it is not a suitable medication for everyone. If you fall under any of the categories described below, do not use Epiduo Gel:

  • If you are allergic to any of the ingredients of Epiduo Gel.

  • If you have not been prescribed Epiduo Gel for your personal use. Please do not use other people’s medication.

  • If you are under 12 years of age.

  • If your skin is sunburnt, damaged or your skin has recently had high exposure to ultraviolet rays.

  • If you are already using another acne treatment that contains Benzoyl Peroxide or a retinoid ingredient.

  • If you are pregnant or breastfeeding.

All medicines may cause side effects in some cases. Epiduo has the potential on occasion to sometimes produce side effects in some people. Some of the side effects that have been reported are:

  • Burning sensation of the skin

  • Skin irritation or redness

  • Dryness of skin, peeling off of the skin, and itchiness

Please let us know if you are taking any other medications so a comprehensive review can be doneEpiduo Gel may interact with other medicines to reduce their effectiveness and vice versa. 

Here are some medications that you should not use with Epiduo Gel:

  • Medicines that increase your sensitivity to sunlight, such as tetracyclines, thiazide water pills, drugs containing sulphur, and quinolone antibiotics

  • Any skin products such as cosmetics or makeup that are harsh, irritating, or cause dryness of the skin

  • Any other acne treatment containing Benzoyl Peroxide or retinoids

  • Medicated or abrasive soap or cleanser, any skin products containing Sulphur, resorcinol, or salicylic acid

You can buy Epiduo Gel Online safely from MedsNow, a pharmacy in the UK. As this is a prescription medicine, our online clinic is able to review your skin and provide you with the right prescription. The medicine is delivered safely to your doorstep.

Epiduo Gel should be stored in a cool (below 25 degrees Celsius) dry place, away from the sight and reach of children. Do not use this medicine after the expiry date, if you find that the medicine with you has expired, talk to your pharmacist to find a safe way to dispose of it. Usually, Epiduo Gel has a shelf life of 3 months after opening the pack.

How Long Should I Use Epiduo Gel for?

You should use Epiduo Gel consistently for 8-12 weeks. After that, it is possible to review the effect this medication has on your skin.

When Should I Use Epiduo Gel?

Epiduo Gel should be used only if it has been prescribed to you for the treatment of your acne. You can use it every night, once before going to bed.

How Long Does It Take for Epiduo Gel to Work?

The time Epiduo Gel takes to improve your skin condition depends on the severity of your acne and response to the medication. Usually, people see a visible improvement in their acne within two weeks of consistent use. Please arrange a review with us if you use Epiduo Gel for 8 weeks with no improvement.

Is Epiduo Gel Safe To Use Whilst Pregnant Or Breastfeeding?

Do not use Epiduo Gel when you are pregnant. If you conceive when using Epiduo Gel, please stop using it and talk to our team about an alternative treatment for acne that is safe to use during pregnancy. The medication should not be used whilst breastfeeding.

Epiduo Gel Is Making My Skin Irritated, Is This Normal?

Sometimes it may take your skin a few weeks to get used to the effect of Adapalene, an ingredient of Epiduo Gel. This causes skin irritation. Usually, it stops in a week or ten days. If the skin irritation persists longer than 14 days, discontinue the treatment and talk to our team about it.

What If I Forget To Use Epiduo Gel?

If you forget to use Epiduo Gel, use it as soon as you remember. Be careful not to expose your skin to sunlight if using Epiduo Gel during the day. If it is almost time for your next dose, then skip the missed dose and continue to use the medication as usual. Do not compensate for the missed dose by applying a double dose.

Can I Use Make-Up With Epiduo Gel?

Yes, you may use makeup with Epiduo Gel. Wait for the gel to dry up before applying any makeup or cosmetics to your skin.

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