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Phenergan (Promethazine)

Phenergan (Promethazine) is a popular and effective antihistamine that blocks the natural histamine that the body produces during an allergic reaction. It is a prescription medication that should be taken according to the doctor's prescription to avoid any severe side effects.
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Phenergan (Promethazine)

Phenergan (Promethazine) is a popular and effective antihistamine that blocks the natural histamine that the body produces during an allergic reaction. It is a prescription medication that should be taken according to the doctor's prescription to avoid any severe side effects.


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Phenergan is the brand name for an antihistamine medication called Promethazine Hydrochloride. It is used to treat hay fever, travel sickness, and skin allergies such as rash, itchiness, and hives. Phenergan is a sedating antihistamine and is also prescribed to those who need help with sleep.

Phenergan tablets are an effective medication for many different conditions. This medication can treat symptoms of allergies such as hay fever, urticaria, insect bites, and stings. It is also helpful for those who have insomnia and need help in falling asleep. Here are some cases wherein Phenergan is useful:

  • To treat allergic reactions such as itchy or runny nose, sneezing, rash, itchy skin, and hives.
  • To prevent or treat motion sickness, vomiting, nausea during travel or sickness caused by vertigo.
  • As a short-term sedative for children – if they need help to fall asleep when they have severe itching.
  • To help with insomnia in adults.

Phenergan contains the active ingredient Promethazine Hydrochloride. Promethazine Hydrochloride belongs to a group of medicines known as phenothiazine medicines. Here’s how it works.

  • For Allergies
    When your body detects allergens, it reacts by producing natural substances known as histamine and dopamine. Both these substances are responsible for triggering allergy symptoms in your body. Taking phenothiazine medications at this time helps relieve your allergy symptoms. Promethazine Hydrochloride blocks the histamine receptors in your brain to reduce the impact of allergies. It also blocks the acetylcholine receptors, which help to reduce a runny nose and cough.

  • For Sleep
    Phenergan is a sedating medication that helps you sleep if you cannot relax due to excessive itching or allergy symptoms. It relaxes your mind and makes you feel more at ease.

  • For Travel Sickness
    Promethazine works to block the receptors in your brain that trigger the vomit reflex. When this part of your brain receives signals of nausea from the nervous system, it reacts by making you feel sick and triggers the vomiting reflex. Promethazine blocks these receptors to help you stop vomiting.

Phenergan offers relief within twenty minutes of taking the first dose. The effect of this medicine lasts for four to six hours, depending upon your prescribed dosage.

Phenergan is an effective medication to relieve allergies, travel sickness, and skin allergies such as urticaria. There are various benefits of taking Phenergan. Some of them are listed below:

  • Phenergan helps people in coping with allergens such as pollen, dust mites, and pet hair.
  • It is an effective medication to treat hay fever, known as allergic rhinitis and allergic reactions of the skin such as rash, itching, and hives or urticaria.
  • Phenergan is a sedating phenothiazine medication. It helps you relax by bringing on a calming effect on the mind – especially when you are suffering from allergies, and helps you sleep.
  • This medication is an excellent option for adults who need help with sleep in the short term. Phenergan is an effective solution for sleep problems due to insomnia or the discomfort caused by allergy symptoms.
  • Phenergan cures vomiting caused by motion sickness, morning sickness, or vertigo
  • Phenergan helps cure cough and cold symptoms such as runny nose or coughing.

Phenergan is a prescription medication and should be taken as per the dosage prescribed by your doctor or pharmacist. Your doctor or pharmacist will assess your allergies or insomnia problems and prescribe the dose you require. The recommended Phenergan dose is as follows:

For Allergies

  1. Children (2 to 5 years) – Use the prescribed dose of Phenergan Elixir in this age group.
  2. Children (5 to 10 years) – One promethazine hydrochloride 25mg tablet at night. In severe allergy cases, your doctor may increase this to one promethazine hydrochloride 25mg tablet twice a day.
  3. Children over 10 years of age & Adults – One promethazine hydrochloride 25mg tablet at night. In severe allergy cases, your doctor may increase this to one promethazine hydrochloride 25mg tablet twice a day.

For Motion Sickness

  1. Children (2 to 5 years) – Use the prescribed dose of Phenergan Elixir in this age group.
  2. Children (5 to 10 years) – One promethazine hydrochloride 10mg tablet at night before travel.
  3. Children over 10 years of age & Adults – One promethazine hydrochloride 25mg tablet at night before travel. Repeat in six to eight hours if necessary.

For Sedation

  1. Children (2 to 5 years) – Use the prescribed dose of Phenergan Elixir in this age group.
  2. Children (5 to 10 years) – One promethazine hydrochloride 25mg tablet at night.
  3. Children over 10 years of age & Adults – One promethazine hydrochloride 25mg or one 50mg tablet at night. Do not exceed the prescribed dose.

Take Phenergan as prescribed by your doctor or pharmacist. They will assess your health and recommend the correct dosage depending on your requirement. Your doctor will also give you the correct direction for using the medication. It is also a good idea to read the patient information leaflet available in the pack for instructions of use. Here is the recommended way to use Phenergan:

  • Take Phenergan at bedtime or before meals.
  • When taking Phenergan for travel sickness, take the dose one hour before travelling.
  • When taking Phenergan before surgery, take the dose at bedtime the night before the surgery.
  • To help with sleep, take the medication twenty to thirty minutes before bed.
  • If taking Phenergan in liquid form, measure the prescribed amount of medication with a syringe or the dose-measuring spoon or medicine cup provided with the pack.
  • Your dosage is based on your age, medical condition, and response to the treatment. Do not give your medication to someone else without advice from a doctor.
  • Also, do not increase or reduce your dose without a doctor’s advice.

Some key facts that you should know before taking Phenergan are listed below.

  • Alcohol can increase the risk of side effects of Phenergan. Avoid drinking alcohol when taking Phenergan.
  • Phenergan takes up to 20 minutes to take effect. Its effect lasts for four to six hours.
  • Phenergan should not be given to children below the age of two years. It can cause breathing problems in young children.
  • If any of the below conditions apply to you, do not take Phenergan without consulting your doctor:
    a. You are over 65 years old.
    b. You have kidney or liver problems.
    c. You suffer from asthma, bronchitis or a condition called bronchiectasis (persistent widening of the airways due to lung infections or other diseases)
    d. You have heart disease.
    e. You have closed-angle glaucoma
    f. You have epilepsy or any other condition that makes you susceptible to convulsions.
    g. You have a blockage of the opening from the stomach into the intestines.
    h. You have a problem passing urine, for example, in men with the enlarged prostate gland.

Phenergan is an effective medication to treat allergic rhinitis, seasonal allergies, and skin allergies. However, in some cases, it may not be a suitable medication – given prevailing medical conditions or comorbidities of the patient. Here’s a look at some cases where Phenergan is not recommended:

  • For children below two years of age.
  • If you are allergic to Promethazine Hydrochloride or any other ingredients of Phenergan, do not take this medication.
  • If you are taking anti-depressants like monoamine oxidase inhibitor (MAOI). You should also not take Phenergan if you have taken MAOI in the last fifteen days.
  • If the person is unconscious (in a coma) or suffers from severe dizziness, drowsiness, or headaches.
  • If you have hearing problems.
  • You have had something called Reye’s Syndrome or possible Reye’s Syndrome (signs include being sick and confused following a viral illness)
  • You are lactose or sorbitol intolerant
  • You are going to get yourself tested for allergies
  • You are pregnant or are trying to get pregnant.
  • You have prostate-related problems.
  • You have had breathing problems for a long time, such as chronic obstructive pulmonary disorder (COPD)

Just like any other medication, some side effects have been associated with Phenergan. Generally, the observed Phenergan side effects are not severe or harmful. Some of the common side effects associated with Phenergan:

  • Allergic reactions such as rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue.
  • Liver problems such as jaundice (with yellowing of eyes or skin)
  • Stiffness of muscles or tremors.
  • Losing control of muscles in your head or face.
  • Unusual movements of the tongue, facial muscle spasms, rolling eyes, and trembling.
  • Fast, irregular, forceful heartbeat, also known as palpitations
  • Tiredness/fatigue that lasts for a long time. The reason could be anaemia, a blood problem.
  • Over-active behaviour in children.
  • Dry mouth, blurred vision, cannot pass urine
  • Feeling drowsy or sleepy, fatigue, nightmares, headaches, restlessness
  • Loss of appetite (anorexia), indigestion
  • Dizziness, light-headedness, fainting
  • Confusion – especially in the elderly
  • Sensitivity to the sun
  • Restless legs syndrome

Drug interactions can change the way medicine affects your body, and it may impair the effect of one or both medications, increasing the risk of side effects. Share a list of all the medications you use with your doctor at the time of consultation. Include over-the-counter medicines and herbal medicines also in this list. This will help your doctor recommend the most suitable medicine to treat your allergies. Here are some medications that should not be taken alongside Phenergan:

  • Antihistamines applied to the skin, such as diphenhydramine cream, ointment, or spray, and metoclopramide.
  • Any other medicine that causes drowsiness or dizziness.
  • Opioid painkillers, cough relievers such as codeine, hydrocodone
  • Drugs for sleep or anxiety, such as alprazolam, lorazepam, zolpidem
  • Muscle relaxants such as carisoprodol, cyclobenzaprine

You can buy Phenergan online safely in the UK from MedsNow online pharmacy. Place the order for the medication from the convenience of your home. You may also take an online consultation with our doctors or pharmacists. The medicine is delivered discreetly to your doorstep.

The best way to store Phenergan is to keep it away from direct light and sunlight. Keep it in a cool or dark place with a temperature below 30 degree Celsius. Keep the medicine out of sight and reach of children. Do not take Phenergan if the expiry date stated on the label is passed. Store in the original container for the best protection.
Do not throw expired medicines away in the trash. Ask your pharmacist for the best method to dispose of the medicines in a way that is not harmful to the environment.

No. Phenergan is a prescription-only medication in the UK. You cannot buy Phenergan over-the-counter. You will need to consult a doctor and get the proper prescription to buy this medication.

Is it Safe to Use Phenergan if Pregnant or Breastfeeding?
Phenergan should only be used during pregnancy or breastfeeding after consulting the doctor. If your doctor feels that the expected benefit of taking Phenergan will outweigh the potential risks to the baby, then they will prescribe this medication to you. However, in the last few weeks of pregnancy, it is not advisable to take Phenergan, as it has been observed to cause irritability or excitement in the baby after birth. If you are pregnant, breastfeeding or trying to get pregnant, don’t take Phenergan without consulting your doctor.

Will These Tablets Make Me Drowsy?
Yes. Phenergan is a sedating antihistamine medication that is designed to help you relax. It is likely to make you feel drowsy or sleepy within twenty minutes of the first dose. It is advisable not to drive or operate heavy machinery under the effect of Phenergan.

Can I Drink Alcohol While Taking This Product?
It would be best if you did not drink alcohol when taking Phenergan. Alcohol can influence the effect of your medication and may make the drowsiness worse. It can also increase the risk of side effects of Phenergan. It is also recommended to stay away from marijuana when taking Phenergan.

How Long Can I Take These Tablets For?
Do not take Phenergan tablets for more than seven days at a time. If your symptoms are worse or do not improve even after seven days of medication, consult your doctor immediately.

How Long Does Phenergan Take To Work?
After the first dose, Phenergan begins to take effect within twenty minutes. You should experience relief in your allergy symptoms within this time. The effect of Phenergan usually lasts for four to six hours, depending on your prescribed dose.

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