Evorel Sequi

As a continuous sequential HRT, Evorel Sequi is an effective medication for women looking to treat the symptoms of menopause. It comes in the form of a patch. The pack contains two different types of patches. The oestrogen only patches are worn for the first half of the cycle, for the second half of the cycle you will wear the combined oestrogen and progesterone patches. The patches are used in a sequence to try to mirror the body process as best as possible.
Picture of Evorel Sequi
Picture of Evorel Sequi
Picture of Evorel Sequi
Picture of Evorel Sequi
Images for illustrative purposes only

Evorel Sequi

As a continuous sequential HRT, Evorel Sequi is an effective medication for women looking to treat the symptoms of menopause. It comes in the form of a patch. The pack contains two different types of patches. The oestrogen only patches are worn for the first half of the cycle, for the second half of the cycle you will wear the combined oestrogen and progesterone patches. The patches are used in a sequence to try to mirror the body process as best as possible.


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Evorel Sequi is a patch-based alternative HRT for women looking to overcome the various symptoms of menopause. It is especially beneficial to those who are not comfortable with oral medication or may forget to take their pills every day. The patches have to be changed only twice a week and ensure a sequential, steady supply of oestrogen and progesterone to the body. They offer significant relief from symptoms like night sweats, mood swings, hot flushes, and vaginal itching and dryness.

During menopause, your body stops producing an essential hormone called oestrogen, leading to a deficiency of it which causes distressing symptoms. To stop these effects and bring your life back to normal, it is crucial to externally supply your body with what it is no longer producing naturally. Evorel Sequi patches contain two active ingredients, a natural oestrogen (estradiol) and synthetic progesterone (norethisterone) and are essentially used to supplement your body with both these hormones. With a consistent amount of hormone, your body can cope with menopause in a much more comfortable way allowing you to live your daily life conveniently.

One of the primary benefits of using Evorel Sequi patches is that it sequentially supplies the two crucial female sex hormones required for the normal functioning of your body during menopause. In addition to that, these patches are a hassle-free alternative to oral medications since they only have to be changed twice-a-week, i.e. a single patch lasts for up to 3-4 days. Another advantage is that since it is a patch-based external medication, missing doses or accidentally taking too much with it becomes highly unlikely.

Evorel Sequi patches are known as continuous sequential HRT because the regime means it releases both the hormones in sequence. For the first half of the cycle, you have oestrogen alone whereas for the second half of the cycle you have oestrogen and progesterone together. The patches you use for week 1 and 2 are different and will only release oestrogen into your bloodstream, and the ones for week 3 and 4 will supplement both oestrogen and progesterone so that your body can overcome the effects of menopause effectively.

Each pack of Evorel Sequi patches contains half Evorel 50 patches and half Evorel Conti patches. While the Evorel 50 patches contain 3.2 mg of estradiol (releasing 50 micrograms every 24 hours), the Evorel Conti patches have 3.2 mg of estradiol (releasing 50 micrograms every 24 hours). The Evorel Conti patches also contain 11.2 mg of norethisterone acetate (releasing 170 micrograms every 24 hours).

Although it is almost impossible to overdose a patch, if you notice symptoms like breast tenderness or vaginal bleeding, simply remove your current patch and contact your doctor if symptoms persist. If you have forgotten to change your patch as per schedule, you can apply a new one as soon as you remember it. Remember to follow the changing days after that. Avoid doubling the dose by using two patches to make up for a missed one.

Since this is a patch based EvorelSequi supplement, you will apply it directly on the skin. The oestrogen passes from the skin slowly into the bloodstream. The patch needs to be changed twice a week.

When to start using EvorelSequipatch?

You begin using the patch when the menopausal symptoms become too distressing and start to affect your daily life. Normally, you will be using the patch at night so that the oestrogen can enter your body effectively.

Where to apply the EvorelSequipatch?

Once you break open the protective pouch over the patch, apply it directly, without delay onto a clean, dry, and cool patch of your skin. You can apply the EvorelSequi patch onto a hairless area somewhere below your waist. It should remain covered under loose clothing and away from direct sunlight.

Ensure that you:

  • Do not apply the patch twice in the same spot 

  • Do not apply it anywhere near the breasts 

  • Do not apply it on cuts, spots, or inflamed skin

  • Do not apply cream, moisturiser or talcum powder before using the patch

  • Do not wear tight, elasticated waistband clothing when applying the patch

How to put the patch on?

  • Step 1 How to open and peel the EvorelSequi patch
    The notches work as a guide, and you have to tear along the two edges. Then, bend and peel half of the strip while the protective backing faces you.

  • Step 2 How to apply and press the EvorelSequi patch
    Apply the open half of the patch to your skin whilst slowly removing the remaining strip. Firmly press down the patch using your palm to ensure that it is secure. In case you cut the patch, you must use adhesive tape to secure the patch.

Removing an EvorelSequi patch

  1. Start by peeling an edge of the patch away from the skin in a smooth motion.

  1. Slowly remove the entire patch and fold it in half with the sticky side facing inside.

  1. Dispose of it with the household rubbish. Make sure it remains out of the reach of children and pets.

  1. Do not flush used patches.

When you remove the EvorelSequi patch, you might notice some glue remain on your skin. Use warm soapy water to remove the remaining adhesive without damaging your skin. It will go away with time.

Similar to all other medications, Evorel Sequi patches come with their own set of guidelines for safer use. Carefully go through the listicle below.

  • While you may experience spotting during the first few months of using Evorel Sequi patches.

  • If you miss a dose, you might experience spotting, but it will subside soon. In case it continues after a few months of taking the medicine, or after stopping treatment, make sure to consult your doctor.

  • You should undergo regular medical and gynaecological check-ups if you take any HRT to review its effects once a year with your doctor.

  • You should be aware that women using HRT suffer an increased risk of breast cancer, stroke and blood clots in the veins. You need to weigh this risk against the personal benefits of you taking HRT by thoroughly discussing it with your doctor. Consider investing in regular breast examinations and mammograms. You will also have to examine your breasts regularly and immediately report any changes in your breasts to a medical professional.

  • If you have to undergo surgery, particularly abdominal surgery or orthopaedic surgery, your doctor may recommend you cease taking HRT usually four to six weeks prior.

  • Lastly, remember that HRT does not provide contraception for women who are considered fertile for two years after their last menstrual period if under 50, or for one year if over 50. If you are taking HRT and also require contraception please discuss with our team.

This section will highlight specific groups of women who should take extra precautions with HRT medications like Evorel Sequi patches. The reason being, it could affect or trigger some of the existing health conditions in the body. These include women with:

  • Risk or history of developing oestrogen stimulated cancers like breast cancer, or benign breast lumps, fibroids in the womb, endometriosis, endometrial hyperplasia, blood clots in the veins, gallbladder disease, or blood disorders called porphyrias

  • A medicated dose of anticoagulants like warfarin to prevent blood clots 

  • Clinical obesity 

  • Severe varicose veins 

  • Smoking habits 

  • High blood pressure 

  • Diabetes 

  • High cholesterol or triglycerides levels in their blood 

  • A long-term condition called systemic lupus erythematosus (SLE) 

  • Migraines or severe headaches 

  • A tendency to develop irregular brown patches on the skin should minimize their exposure to the sun or UV light while taking HRT

There are certain risks you already face that could get triggered with an HRT. So Evorel Sequi patches become an unsuitable treatment option for you. Women who should steer clear of this medication include:

  • Those with or a family history of breast cancer, oestrogen stimulated cancer, endometrial hyperplasia

  • Vaginal bleeding where the cause remains unknown?? 

  • Blood disorders leading to blood clots in the veins 

  • A blood clot in a vein of the leg or pulmonary embolism in the lungs 

  • Inflammation in a vein that has been caused by a blood clot? 

  • A recent encounter with a stroke or heart attack 

  • Angina pectoris 

  • Active liver diseases such as hepatitis, liver cancer 

  • Pregnancy or breastfeeding 

  • Rare hereditary problems of galactose intolerance, fructose intolerance, etc

Like every other medication, it is obvious that overdosing or improper use of Evorel Sequi patches could also trigger certain side effects in some women. This section will list down all possible side effects you should look out for to avoid any complications. These include:

  • Headaches 

  • Breast tenderness 

  • Painful periods 

  • Irritation on the area of the skin where the patch is applied

  • Changes with your menstrual cycle

There are various medicines whose ingredients interact negatively with each other leading to complications. That is why it would be wise to inform your healthcare provider about all the other medications you are taking currently before beginning with Evorel Sequi patches, including:

  • aprepitant 

  • bosentan

  • carbamazepine

  • efavirenz

  • eslicarbazepine

  • fosaprepitant

  • fosphenytoin

  • modafinil

  • nevirapine

  • oxcarbazepine

  • phenobarbital

  • phenytoin

  • primidone

  • rifabutin 

  • rifampicin 

  • ritonavir 

  • rufinamide 

  • the herbal remedy St John's wort (Hypericum perforatum)

  • topiramate

The ideal way to order your medication from the comfort of your home is to place an order with trusted online clinics such as MedsNow. Since you can only get Evorel Sequi patches with a valid prescription, you will need to undertake a quick, free, and simple online consultation. That will help determine whether Evorel Sequi patches are an ideal treatment option for your needs and if it is safe and effective for you. Your order will be delivered to you discreetly.

Store Evorel Sequi patches in a cool, dry place away from direct heat and light. Make sure it remains hidden from the sight and reach of children.

Does Evorel Sequi work?
Yes, Evorel Sequi is an effective HRT treatment for overcoming the distressing symptoms of menopause. It relieves both physical symptoms like hot flushes, night sweats, osteoporosis, insomnia, and vaginal dryness as well as psychological ones including mood swings, depression, and irritability.

How long does Evorel Sequi take to work?
You will find relief from your menopausal symptoms within the first few weeks of using the Evorel Sequi patches. However, complete comfort will only arrive after a few months of consistent use. If you fail to experience any change in your symptoms, talk to our team to raise your dosage or shift to a different HRT.

Can I delay a period on Evorel Sequi?
Although the patches do cause a menstrual bleed at the end of each monthly cycle, there is no evidence to prove that it could help you delay a period.

When should I bleed on Evorel Sequi?
Week 4 marks the withdrawal bleed when using Evorel Sequi patches, i.e. the week before you finish a pack.

Can I order Evorel Sequi online?
Yes, you can order these patches online from MedsNow.

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