Kliovance

Kilovance, a form of HRT reduces the symptoms of menopause, including night sweats, hot flushes, fatigue, mood changes and bone mineral loss due to osteoporosis. It contains two sex hormones, an oestrogen called estradiol and progesterone called norethisterone acetate. HRT is widely accepted to be a safe and effective relief from menopausal symptoms whilst needed.
Picture of Kliovance
Picture of Kliovance
Picture of Kliovance
Picture of Kliovance
Images for illustrative purposes only

Kliovance

Kilovance, a form of HRT reduces the symptoms of menopause, including night sweats, hot flushes, fatigue, mood changes and bone mineral loss due to osteoporosis. It contains two sex hormones, an oestrogen called estradiol and progesterone called norethisterone acetate. HRT is widely accepted to be a safe and effective relief from menopausal symptoms whilst needed.


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Kliovance is an HRT that alleviates the discomforts caused by menopause by restoring hormonal imbalances so that you can be more comfortable through menopause. It works well for women who are in menopause and are no longer having monthly periods. In addition to offering relief from menopausal symptoms, Kliovance is also recommended for some women for the prevention of osteoporosis.

Women over 45-55 years old who have not had their uterus removed post-menopause may have to endure various symptoms due to the lack of oestrogen production in their body. These include hot flushes which cause a spontaneous heat feeling to spread throughout the body, leading to flushing, blushing, sweating and fast heartbeat, night sweats, and dryness/soreness of the vagina. Kliovance helps alleviate these symptoms by replenishing the oestrogen in the body.

Estradiol is a type of oestrogen produced in the female body that promotes the development and maintenance of feminine characteristics. Menopause marks reduced oestrogen production causing menopausal symptoms to arise. Kliovance contains two active ingredients an oestrogen (estradiol hemihydrate) and progesterone (norethisterone acetate). Upon regular consumption, the tablet substitutes the hormonal imbalance, thereby overcoming the uncomfortable symptoms and allowing a woman to lead a more comfortable life.

One of the primary advantages of taking any HRT medication including Kliovance is that it restores the lack of natural oestrogen in the body, in turn lowering the effect of the symptoms that arrive with menopause. HRTs are generally recommended for medium-term treatment of menopausal discomforts. Talk to our team about the appropriate dosage and duration of the medication.

Each Kliovancetablet contains 1mg of estradiol and 0.5mg of norethisterone. The package consists of 84 tablets which last for about three months. Since the medication aims to restore the natural oestrogen in your body, we may advise you to begin with a low dose to review its effects safely before moving onto a higher dosage.

Kliovance is available as a calendar pill, i.e. you will take one pill each day for 28 days continuously without a break and then move onto the next pack immediately upon completion. In case you find no change in your symptoms because the dosage is too low, you can talk to our team for a higher dose. Although we would begin with the lowest dose for as short a time as possible, you can try a higher dosage if you do not feel your symptoms are adequately treated. Please arrange a review if you would like to discuss a higher dosage or any adjustments to the treatment regime.  

You need to swallow your tablet whole, with plenty of water. You can take it with or without food but do not suck, crush or chew the tablet. Make sure you read the patient information leaflet thoroughly before starting with the medication. Use alarms and reminders to avoid missing a dose as this could lead to spotting.

Like every medication, Kliovance also has specific information, which you need to know and understand before beginning it. In addition to reading it here, you can also find these guidelines in the patient information leaflet, so make sure you read them thoroughly.

  • While you may experience spotting during the first few months of taking Kliovance, you will not necessarily face a monthly withdrawal bleed.

  • If you miss a dose, you might experience spotting, but it will generally subside within a few months. In case it continues after 6 months of taking the medicine, or after stopping treatment, make sure to consult your doctor.

  • You should undergo regular medical check-ups if you take any HRT to review its effects once a year with our team/your GP.

  • You should be aware that women using HRT may have a slightly higher increased risk of breast cancer, stroke and blood clots in the veins. You need to weigh this risk against the personal benefits of you taking HRT by thoroughly discussing it with our team and ensuring you understand the risks before taking the treatmentPlease make sure you are checking your breasts for lumps or bumps at least once a week at homeImmediately report any changes in your breasts to your GP.

  • If you have to undergo a surgery, particularly abdominal surgery or orthopaedic surgery, your doctor may recommend you pause taking HRT usually four to six weeks prior.

  • Lastly, remember that HRT does not provide contraception for women who are considered fertile. You may remain fertile for two years after your last menstrual period if under 50, or for one year if over 50. If you are taking HRT and also require contraception, please contact us for a review and to discuss the possible options.

While most women can rely on Kliovance to relieve the symptoms of menopause, some groups should exercise extra care. That is because these women could already be suffering from certain conditions that might worsen due to this medication. Women who should use Kliovance with caution include the ones with:

  • Risk or history of developing oestrogen stimulated cancers like breast cancer, or benign breast lumps, fibroids in the womb, endometriosis, endometrial hyperplasia, blood clots in the veins, gallbladder disease, or blood disorders called porphyrias

  • a medicated dose of anticoagulants like warfarin to prevent blood clots

  • Clinical Obesity 

  • Severe varicose veins 

  • Smoking  

  • High blood pressure 

  • Diabetes 

  • High cholesterol or triglycerides levels in your blood 

  • a long-term condition called systemic lupus erythematosus (SLE)

  • Migraines or severe headaches

Avoid this HRT if you are allergic to one or any of Kliovance ingredients. Remember to inform your doctor or pharmacist if you have experienced an allergy to determine an alternative treatment for you. Listed below are groups of women who are unsuitable candidates for Kliovance. These include women with:

  • Active or previous breast cancer, those with a family history of breast cancer with a high genetic risk, oestrogen stimulated cancer, endometrial hyperplasia

  • Vaginal bleeding of unknown cause

  • Blood disorders leading to blood clots in the veins

  • A blood clot in a vein of the leg or pulmonary embolism in the lungs

  • Inflammation in a vein that has been caused by a blood clot

  • A recent stroke or heart attack

  • Angina pectoris

  • Active liver diseases such as hepatitis, liver cancer

  • Pregnancy or breastfeeding

  • Rare hereditary problems of galactose intolerance, fructose intolerance, etc

The most commonly occurring side effects of Kliovance include:

  • Breast pain or breast tenderness 

  • Headache, migraine, mood change

  • Weight gain 

  • Nausea 

  • Headaches

There are some medicines which interact with Kliovanceand should be avoided in combination. You must inform your GP or pharmacist if you are taking or plan to take the following:

  • Epilepsy medicines (e.g. phenytoin, carbamazepine)

  • Hepatitis C medicines (e.g. telaprevir)

  • St Johns Wort

  • Antifungal medicines containing ketoconazole

  • Tuberculosis medicines (e.g. rifampicin)

  • HIV medicines (e.g. nevirapine, ritonavir, nelfinavir)

The ideal way to order your medication from the comfort of your home is to place an order with MedsNow. Since Kliovance is a prescription-only HRT, you will need to undertake a quick, free, and simple online consultation, which will help determine if Kliovance is an appropriate treatment option for you, and your prescription can be arranged. Once your order is placed, you can expect discreet delivery of your medicines to your doorstep.

You should store Kliovance in a cool, dry place away from direct heat and light. Make sure it remains hidden from the sight and reach of children.

What if I use too much Kliovance?
Overdosing on Kliovance can lead to vomiting and feeling sick. In case you take too much of this medication, contact a healthcare professional immediately.

What if I forget to take this medication?
In case you miss a dose, take it within the next 12 hours and then continue with your usual medication schedule.

Can I use Kliovance just before or after surgery?
Ideally, you should inform your surgeon that you are taking this medication if you will be going through surgery. They may ask you to stop taking Kliovance about 4-6 weeks prior to your operation to reduce the risk of blood clots.

How good is Kliovance?
Kliovance is a reliable medication that can help you overcome the various symptoms of menopause effectively.

How long does it take for Kliovance to work?
You will start to notice the initial signs within a couple of weeks while the full effect could take up to three months depending on your body's response to the medication.

What type of HRT is Kliovance?
Kliovance is a continuous combined Hormone Replacement Therapy.

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