Amitriptyline

A tricyclic antidepressant recommended to those suffering from migraine headaches. Although, Amitriptyline is also used to treat mood and pain conditions such as depression and arthritis it can also be used as a prophylactic medication for preventing a migraine headache.
Amitriptyline 10 mg Tablet
Picture of Amitriptyline
Picture of Amitriptyline
Picture of Amitriptyline
Amitriptyline 10 mg Tablet
Picture of Amitriptyline
Picture of Amitriptyline
Picture of Amitriptyline
Images for illustrative purposes only

Amitriptyline

A tricyclic antidepressant recommended to those suffering from migraine headaches. Although, Amitriptyline is also used to treat mood and pain conditions such as depression and arthritis it can also be used as a prophylactic medication for preventing a migraine headache.


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One of the oldest medication for migraine, Amitriptyline was originally used to treat depression and anxiety. However, when taken at a low dose, it works as migraine medication and effectively prevents severe migraine headaches.

Uses of Amitriptyline include:

  • Migraine treatment, i.e., preventing migraine pain and chronic headaches

  • Treating nerve pain

  • Treating depression and anxiety

  • Treating nocturnal enuresis (bedwetting) in children

  • Treating arthritis pain

Amitriptyline increases the serotonin levels in the brain. And since serotonin improves the emotional state, mood, and sleep quality in human beings, its increased levels change the way the body responds to migraine headaches.

Amitriptyline, as soon as a patient starts taking it, improves the quality of sleepWithin six weeks of taking it, the medication can have significant changes in terms of improving mood and reducing pain.

Amitriptyline tabletare swallowed with waterDoctors usually suggest taking one tablet a day before bedtime since the migraine medication may cause drowsiness.

The smallest Amitriptyline migraine dosage is 10 mg. However, the drug is also available in tablets of larger dosesDoctors usually recommend between 25 and 150 mg and will start you on a small dose. The dosage is increased every few days depending on how effective the previous dose was.

Here are a few facts you must know about Amitriptyline, one of the most effective migraine preventive medications:

  • Amitriptyline usually helps migraine patients feel better within two weeks. However, for some patients, this duration may increase up to six weeks.

  • Stopping this migraine treatment suddenly can have Amitriptyline withdrawal side effects. So, make sure to tell your doctor if you want to stop it.

  • Amitriptyline must be taken every day for it to be effective.

Most adults over the age of eighteen can take Amitriptyline. However, let your doctor know if you:

  • Are allergic to Amitriptyline.

  • Have a heart condition.

  • Have liver or kidney problems.

  • Have a blood disorder.

  • Are pregnant or breastfeeding.

  • Have epilepsy.

  • Have suicidal thoughts.

  • Have diabetes.

  • Have taken depression medication in the past.

Amitriptyline may have some mild side effects, such as:

  • Drowsiness

  • Nausea 

  • Fatigue

  • Dry Mouth

  • Constipation

  • Headaches

  • Blurred vision

  • Difficulty urinating

  • Tingling sensation in hands and feet

  • Balance problems

  • Confusion

  • Change in appetite

  • Weight loss or gain

Some serious side effects of Amitriptyline may include:

  • Faintness

  • Severe chest pain

  • Rapid or irregular heartbeat

  • Trouble speaking

  • Swelling of face or tongue

  • Skin rash

  • Jaw, neck, back or muscle spasms

  • Hallucinations

  • Unusual bleeding or bruising

  • Seizures

  • Monoamine oxidase (MAO) inhibitors

  • Antihistamines?

  • Nardil, Eldepryl, and Parnate

  • Diet pills

  • Antabuse

  • Ismelin

  • Tambocor

  • Phenobarbitol

  • Medication for irritable bowel disease, thyroid, mental illness, nausea, Parkinson’s disease, urinary problems, and ulcers.

Note: Check the patient leaflet for the complete list of medical interactions 

Store Amitriptyline away from light in a dry place below 25 degree Celsius.

You can receive Amitriptyline tablets right where you are through the UK-based online pharmacy, MedsNow. At MedsNow, you can consult certified and experienced doctors online and receive the right medication advice and dosage for migraine headaches.

Can I drink alcohol with Amitriptyline?
Amitriptyline and alcohol can be a bad combination since they may cause sleepiness, dizziness, and blurred vision. The effects can get worse if the patient consumes alcohol at the time of starting the treatment or after the dosage increases.

Is it safe to take Amitriptyline for a long time?
Amitriptyline is not addictive and can be taken for a long time without any side effects.

What will happen when I stop taking Amitriptyline?
Stopping Amitriptyline consumption suddenly can have some side effects such as nausea, headache, fatigue, etc.

Will Amitriptyline affect my sex life?
High doses of Amitriptyline can affect sex life in some people.

Will Amitriptyline affect my fertility?
High doses of Amitriptyline can have effects on fertility. This may be in cases where Amitriptyline is used to cure depression.

Is Amitriptyline safe to take if pregnant?
Amitriptyline medication for migraine can be problematic for the baby and is therefore not recommended for use in pregnant women. Check with your doctor before taking Amitriptyline if you are pregnant.

Is it safe to breastfeed while taking Amitriptyline?
Since Amitriptyline may be harmful to the baby, check with your doctor before taking this migraine medication if you are breastfeeding.

How long should I take Amitriptyline for?
Amitriptyline can be taken for months or even years if it works well for you.

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